Performing all the farming practices, sustainably is the key to achieve agricultural sustainability. It is necessary for conservation and enhancement of the natural resources such as soil, water, plant and animal diversity, vegetation cover, renewable energy sources, climate, and ecosystem services, which are considered the fundamentals for healthy, long-term functioning of agriculture. However, it is a necessity to guarantee the food security of the rising population. Development and implementation of novel nutrient management practices and fertilization technologies will open up the way to uplift the crop yields and close the gap between actual and attainable yield to ensure food security. Therefore, this article’s main idea is to review the worthiness of using nanofertilizers to attain sustainability of agriculture.