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Rational Design of Trametinib Analogues for MEK1 Inhibition An In Silico Approach

Trametinib, a selective MEK inhibitor, is widely used in the treatment of several cancers. This study aimed to designtrametinib analogues with enhanced MEK1 inhibition using an in silico strategy. Structural modifications to the trametinib scaffold were explored through molecular docking. A library of 34 compounds was assessed, among which compounds 1C and 2R demonstrated more …

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Trust and Transparency: Investigating University Students’ Attitudes Toward Responsible AI

As Artificial Intelligence (AI) becomes increasingly embedded in higher education, concerns surrounding Responsible Artificial Intelligence (RAI), particularly trust and transparency have moved from abstract ethical discussions to practical institutional challenges. While existing research has largely focused on technological capabilities and learning outcomes, empirical evidence on university students’ perceptions of Responsible AI remains limited, especially in …

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