Trametinib, a selective MEK inhibitor, is widely used in the treatment of several cancers. This study aimed to designtrametinib analogues with enhanced MEK1 inhibition using an in silico strategy. Structural modifications to the trametinib scaffold were explored through molecular docking. A library of 34 compounds was assessed, among which compounds 1C and 2R demonstrated more …

Rational Design of Trametinib Analogues for MEK1 Inhibition An In Silico ApproachRead More

Environmental pollution in Sri Lanka has intensified due to rapid urbanization and industrial growth, significantly impacting the nation’s biodiversity and ecosystem health. While technological advancements can contribute to environmental degradation, they also offer promising solutions for environmental protection. This review examines the dual role of technology in Sri Lanka’s environmental context, analyzing both its adverse …

The Impact of Technological Advancements on Environmental Pollution in Sri LankaRead More

Metallodrugs, which contain metal ions as active components, exhibit promising therapeutic effects compared to conventional organic drugs. This review explores various classes of metallodrugs, including platinum-, gold-, and ruthenium-based compounds, and their biomedical applications in treating cancer, bacterial, and inflammatory diseases. Despite their advantages, metallodrugs face challenges such as toxicity, selectivity, cost, and stability issues. …

Recent Progress in Using Nanotechnology to Improve Metal-Based DrugsRead More

Sri Lanka’s energy sector is undergoing a critical transformation as the nation aims to achieve carbon neutrality and enhance energy security amid growing demand and resource constraints. This paper explores the country’s energy transition from conventional fossil-based systems toward renewable and sustainable alternatives. It assesses the current energy mix, government policies, and strategic frameworks such …

Energy Transition and Sustainability Challenges in Sri Lanka – A Policy PerspectiveRead More

Nanomaterials have gained growing importance in modern science and technology due to their exceptional self-cleaning and antibacterial properties. This review explores recent advancements in nanotechnology, emphasizing the mechanisms behind these functionalities and their wide-ranging applications in medicine, construction, textiles, and environmental protection. Self-cleaning properties are mainly achieved through superhydrophobicity and photocatalysis, while antibacterial effects arise …

Advances in Nanomaterials – Self Cleaning and Antibacterial ApplicationsRead More