Boiler explosions around the world generate serious damage in workplaces and injuries to employees, which range from burns and lacerations to death, with the ensuing financial costs for the operating enterprises. Both in industrial and institutional settings, the main cause of boiler explosions is low water level which generates boiler tube overheating, sudden vaporization, rapid increase in pressure, and catastrophic failure. However, few computational tools have been developed to calculate these consequences for boilers. Preventing such accidents is critical in industry and the health sector, as their utilities services must be intrinsically safe to meet their economic and humanitarian mission, respectively. This article reviews the technical requirements for the safe operation of boilers focusing on the correct location and distancing of the boiler room to minimize domino-effects, and injuries to humans.